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Obesity and Diabetes
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People with overweight are at risk of developing serious health problems such as heart disease, stroke, cancers, as well as diabetes. Obesity increases the incidence of type II diabetes, because an overweight person has less sensitivity towards insulin. This is because fat cells are more resistant to insulin. Fat cells release a novel protein called PEDF (pigment epithelium-derived factor), which triggers a chain of events and interactions that lead to development of Type 2 diabetes. It was shown that, increasing PEDF causes Type 2 diabetes and blocking PEDF can reverse these effects. More than 85% of people with type 2 diabetes were found to be overweight.

Losing at least 5 - 7 % of the body weight by work out can make a big difference.  One can reduce the risk of developing diabetes by reducing the body weight to about 7 to 10 pounds. Even with diabetes, obese people can reduce the progression of the disease by loosing weight along with blood pressure and cholesterol levels.
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